The game’s storyline follows the aftermath of worldwide chemical warfare where few begins survived. The remaining humand are divided in two factions: Survivors, trying to rebuild the world in a sustainable way and mutants doing opposite.

Our main character has a mobile shelter where he cares for his canine friends, now that dogs has become a food source for mutants. The Last Friend must avoid the mutants by using defenses placed arpund his trailer and the superhuman fighting abilities he has developed.