You will need at least 500 MB of free disk space to install Screeps. Provided that you have at least an NVIDIA GeForce 510 graphics card you can play the game. The minimum memory requirement for Screeps is 4 GB of RAM installed in your computer. An Intel Core 2 Duo E8400 CPU is required at a minimum to run Screeps.
Screeps will run on PC system with and upwards. Additionally it has Mac and Linux versions.