In terms of game file size, you will need at least 60 MB of free disk space available. CrossCells system requirements state that you will need at least 2 GB of RAM. The cheapest graphics card you can play it on is an NVIDIA GeForce 6100. To play CrossCells you will need a minimum CPU equivalent to an Intel Pentium 4 2.00GHz.
CrossCells will run on PC system with Windows Vista or later and upwards. Additionally it has Mac and Linux versions.