Provided that you have at least an NVIDIA GeForce 510 graphics card you can play the game. You will need at least 100 MB of free disk space to install Pixelmash. An Intel Core 2 Duo E8400 CPU is required at a minimum to run Pixelmash. The minimum memory requirement for Pixelmash is 1 GB of RAM installed in your computer.
Pixelmash will run on PC system with Windows 7 or newer and upwards. Additionally it has a Mac version.