Guinea-Pig system requirements state that you will need at least 1 GB of RAM. Additionally, the game developers recommend somewhere around 2 GB of RAM in your system. The cheapest graphics card you can play it on is an NVIDIA GeForce 7200 GS. Futhermore, an NVIDIA GeForce 8500 GT is recommended in order to run Guinea-Pig with the highest settings. An Intel Core i3-530 CPU is required at a minimum to run Guinea-Pig. However, the developers recommend a CPU greater or equal to an Intel Pentium 4 2.00GHz to play the game. In terms of game file size, you will need at least 200 MB of free disk space available. Make sure your have 250 MB of free disk space in order to install Guinea-Pig.
Guinea-Pig will run on PC system with Win XP SP3 / Vista / Windows 7 / Windows 8 and upwards.