The cheapest graphics card you can play it on is an NVIDIA GeForce 510. To play PUSS! you will need a minimum CPU equivalent to an Intel Core i3-530. However, the developers recommend a CPU greater or equal to an Intel Core i5-650 to play the game. You will need at least 750 MB of free disk space to install PUSS!. PUSS! system requirements state that you will need at least 2 GB of RAM. Additionally, the game developers recommend somewhere around 8 GB of RAM in your system.
PUSS! will run on PC system with Windows 7 or later and upwards. Additionally it has a Mac version.