In terms of game file size, you will need at least 7 GB of free disk space available. The cheapest graphics card you can play it on is an ATI Radeon HD 5850. The minimum memory requirement for Synstasis is 4 GB of RAM installed in your computer. An Intel Core i5-750 CPU is required at a minimum to run Synstasis.
Synstasis will run on PC system with Windows® 7 (SP1) / Windows® 8 / Windows® 8.1 / (64-bit only) and upwards. Additionally it has a Linux version.